Endocrine Abstracts

Prolactinomas are the most common hormone-secreting pituitary tumors. They have good response for conservative treatment. In the time of diagnosis large pituitary tumors unrarely can cause hypopituitarism. We have two cases of partially or totally recovery of hypopituitarism in consequence of effective dopamine agonists use. The 24-years man with large prolactinoma (prolactin 52 times higher) and laboratory markers of panhypopituitarism had total recovery in 1 year of cabergol...

Introduction: Prolactinomas are the most common tumors among hormonally active pituitary adenomas. Therapy with dopamine agonists (DA) remains the first treatment choice. However there remain definite numbers of prolactinomas resistant to standard DA therapy. The underlying mechanisms of this phenomenon, management and prognosis are still poorly understood. The search of treatment options for overcoming DA-resistance is an important object in practical endocrinology. We presen...

Introduction: The combination of poly/monostotis fibrous dysplasia, café-au-lait pigmentation of the skin and endocrine hyperfunction (mostly precocious puberty) is known as McCune–Albright syndrome (MAS), a genetic origin syndrome with low incidence. The molecular basis of MAS is a mosaic activating mutation of the α subunit of the G protein (Gsα) gene.We present a clinical case of a 10-year-old boy with partial MAS and GH-secreting ...

Introduction: There are contradicting data about bone mineral density (BMD) in patients with type 2 diabetes mellitus (DM), although most studies describe increased BMD values in them. Due to this finding it is not clear how tightly bone fragility is bound with BMD in type 2 diabetic people.Design: We provided dual-energy X-ray absorptiometry of lumbar spine and proximal femur to 46 postmenopausal women with type 2 diabetes mellitus (DM), 14 of them had ...

Introduction: The diabetes mellitus (DM) is the known risk factor of fractures. The aim was to determine predictors of fractures in type 2 diabetic postmenopausal women without hyperparathyroidism.Design: We analyzed local trauma clinic data for 3 sequential years from 2 662 diabetic persons who were entered The National Register of diabetes mellitus patients (133 subjects with type 1 diabetes mellitus and 1995 ones with type 2 DM). Afterward we examined...

Background and aims: The aim was to determine psychoemotional state in diabetic and non-diabetic patients with or without fractures and its correlation with bone condition.Materials and methods: We examined 62 postmenopausal women with type 2 diabetes mellitus (DM), 29 of them had bone fracture within last month. The control group included 56 non-diabetic women, 26 within a group were recently fractured. Groups were comparable in body mass index, age, du...

Abstract: There are few studies of the cellular immunity in men with obesity and hypogonadism. The aim was to study the parameters of cellular components of the immune system in patients with obesity and hypogonadism.Materials and methods: The study included 120 men aged 40–65 years with obesity (mean BMI – 35±5.6 kg/m2). Patients were divided into two groups depending on the level of total testosterone (T). The first group incl...

Late identification and inadequate assessment of cardiovascular risk factors are being considered as the main cause of high mortality in men with type 2 diabetes mellitus (T2DM).Aim: To analyze the carbohydrate metabolism, levels of testosterone, proinflammatory cytokines in patients with T2DM and obesity.Methods: We examined 123 men with T2DM and obesity (mean age – 53.8±6.8). Parameters of carbohydrate metabolism, total...

Currently actively studied the role of certain inflammatory and proinflammatory cytokines in the pathogenesis of insulin resistance, type 2 diabetes, obesity, atherosclerosis. However, the influence of testosterone deficiency on the balance of proinflammatory cytokines is unexplored. The aim of the work was to evaluate the influence of testosterone deficiency on metabolic parameters and levels of proinflammatory cytokines in patients with obesity and type 2 diabetes.<p cla...

It is well known that type 2 diabetes causes the endothelial dysfunction. However, insufficient attention is paid to the role of androgen deficiency in the formation of the early signs of endothelial dysfunction. The aim of the work was to evaluate the relationship between testosterone deficiency and markers of endothelial dysfunction in men with type 2 diabetes.Materials and methods: Were examined 88 men aged 40–65 years with type 2 diabetes. All p...